Delayed Dicoumarol Intoxication

Delayed leukoencephalopathy after acute carbon monoxide intoxication.

Delayed leukoencephalopathy is an uncommon complication of hypoxic-ischemic events of different etiologies, including carbon monoxide intoxication. We present a case of a 40-year-old male patient who was admitted with rapidly progressive neurocognitive and behavioral deficits. There was a history of accidental carbon monoxide intoxication one month before, presenting with loss of consciousness ...

Delayed encephalopathy following carbon monoxide intoxication.

The case history and CT scan of a patient with delayed encephalopathy following carbon monoxide intoxication are described. The patient recovered. The CT scan revealed symmetrical areas of decreased density at the level of the globus pallidus. This case differs in several ways from other cases of carbon monoxide intoxication in which abnormalities of the CT scan were found.

The biosynthesis of dicoumarol.

Micro-organisms have been isolated that can utilize o-coumaric acid as a sole carbon source with the subsequent production of 4-hydroxycoumarin and dicoumarol. One of these organisms, Penicillium jenseni, has been used to examine the biosynthesis of dicoumarol. Certain thermophilic fungi have also been found that can convert o-coumaric acid into dicoumarol.

Delayed encephalopathy after carbon monoxide intoxication: prognosis is still uncertain.

Prothrombin Time in Dicoumarol Therapy.

In the course of controlling dicoumarol therapy given (a) as a postoperative routine to prevent thrombosis (fifty-five cases) and (b) therapeutically in cases of established venous thrombosis (nine cases), certain peculiarities have been observed in the behaviour of the prothrombin time, particularly in relation to dicoumarol haemorrhage. Two sources of thromboplastin have been used, Russell vi...